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It additionally required events to “exercise an efficient control of such a nature as to prevent the illicit worldwide traffic in Indian hemp and especially in the resin”. In the United States in 1937, the Marihuana Tax Act was passed, and prohibited the manufacturing of hemp in addition to hashish. In 2001, Nevada lowered marijuana possession to a misdemeanor and since 2012, a quantity of different states have decriminalized and even legalized marijuana. On 17 October 2015, Australian health minister Sussan Ley offered a model new legislation that may enable the cultivation of hashish for scientific analysis and medical trials on sufferers. Hemp buds (or low-potency hashish buds) laced with synthetic cannabinoids began to be bought as hashish road drug in 2020. Researchers confirmed that THC exerts its most distinguished effects through its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, each of which are G protein-coupled receptors.
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